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Okay I have been trying out this synthesis, iv failed once and I think I know what I did wrong but has anyone successfully done this? I actually have access To TLC now so should be able to see what’s going on a bit better and if it is actually reducing to one substance…. I don’t see how it...

Yeah. May take another year tho 😂

I say I worked it out…let me clarify. I’m still on the first Henry reaction of 2,5-DMOBA to 2,5-DMONS. That then needs to be reduced to 2c-h, then to the relevant active 2c drug, then to the nbome. I will almost certainly try and make mescaline first…way simpler and less steps. I will reduce...

Oh also with regards to re-x’ing - I figured I would worry about that and do that in a beaker when I actually plan to reduce it… Also, now I think about it - it seemed like there were a lot more crystals in the RB before I had to take time to go grab my glass rod and break it up - then probably...

At least I have NO DESIRE to synthesise anything addictive!

Oh also; I told this to the guy who was helping me to the finish line of the n,n-DMT synthesis via reductive animation - bare in mind everything iv learned about chemistry has been whilst iv been in pretty bad benzodiazepine withdrawal. So sometimes I may make silly mistakes or not be quick...

Yes this is actually what I concluded had happened. I don’t think I realised that it would obviously get stuck in the RB so it took time to break it all up. Next time, I firstly would pre chill the solvent to wash it with but mainly I’d transfer it to a suitable beaker instead of letting it...

Also tbf RT for me is essentially always going to be different as I’m working from my flat… Can I ask, why is it that ammonium acetate is quite often used as a catalyst that works for quite a few Henry reactions using a pretty wide range. Iv seen It used with benzaldehyde to more exotic things...

I’ll try is again…not the end of the world… It was just the fact I stupidly added the GAA all at once and the fact I went 4mins over on time for reflux that I differed my procedure from the 10g example you gave. Oh and I weighed everything - I didn’t go by ml OTHER THAN for the MeOH

Yeah don’t worry I’m not giving up! Yeah - I made notes, in a spreadsheet… Unless my volumetric measure is incorrect it was def 30ml methanol. I did let it go a few mins too long +4 mins too long…I got distracted cleaning something I think…. I also did cool it straight down to RT it just...

Wow I got a pretty horrible yield 1.8g from 10g benzaldehyde annoyingly. I did just kind of chuck the GAA in as opposed to slowly so I’m not too surprised. I’ll probably try it in iso next time too. Cheers for the info bro!

It’s cool I worked it out with the help of someone else on here. There is something about weighing shit I have ALWAYS hated. Probably goes back to when I did sell drugs and wanted to take them and so never prepped them or something I dunno. Maybe my scales are just shit which is why but hey…it...

Oh yeh it went in fridge for a while dw - it was just amazing to watch it crystallise in front of me. Yes I was actually mistaken about the 2c-e. Sorry I was thinking of escaline from 3,4,5-TMOBA…although not sure if that would work either to be clear I mean by going via mescaline as an...

Oh yeah, and as for the actual plan re the LAH - yeah, it’s in original unopened bottle, which I know is sealed, lidded and then vacuum sealed. I added a second layer of vacuum seal with some desiccant in there too. I think I plan to use this to reduce the 2,5-DMOBNS I made today, as well as...

Oh shit it did it! Ha this website is pretty glitchy on my iPhone on the clearnet tbf

Okay it won’t let me upload the video anyway! Ha

Thanks for your reply. I got a BEAUTIFUL crystalline lattice at 30+c! The problem was three-fold I think before… 1. Too much solvent by a factor of 4… 2. Didn’t distill the NM using a friggin’ column… 3. Didn’t add acetic acid… So I had two bottles of GAA from the same source - put one in the...

Wow I really did not anticipate that GAA actually being pure - I opened the bottle worried at first then as soon as I tried pipetting it into the grad cylinder it was hard to weigh as what wasn’t liquid just filled the tube with vapour! so very glad I made an absolute of wearing PPE!