Synthesis of 4'-methylpropiophenone from toluene by Friedel-Crafts reaction (1kg+ scale)

[CryoThio]

Are there any other Lewis acids that can be used to synthesize 4mmc from toluene?

Aluminum chloride is hard to obtain for me.

 

[AgamemnonFromTroy]

Yes, for example Iron chloride (FeCl3) and zinc chloride (ZnCl3) but the reaction will happen at a slower rate compared to using aluminium chloride.

 

[CryoThio]

The zinc and iron chlorides are anhydrous?

Which of those two give the faster reaction?

 

[AgamemnonFromTroy]

Yes they are both anhydrous and from the two iron (iii) chloride (FeCl3) would work the best

 

[AgamemnonFromTroy]

ZnCl2* not ZnCl3

 

[Germanium]

How to synthesize 3-methylpropiophenone?

 

[oneimone]

yo yo. for small synthesis the ratio of substrates are the same 3:1:1,5 or something changes?

 

[The-Hive]

Divided it by 10

 

[The-Hive]

@Frankstone

 

[TucoSalamanca.]

in this synthesis I only have a heater balloon mixer can I not use a water bath and how many degrees should not exceed when we add propinol chloride

 

[TucoSalamanca.]

This synthesis is AlCl3.6H2O, can I use this as a catalyst?

 

[CryoThio]

I'm pretty sure it has to be anhydrous aluminum chloride.

No water, whatsoever. Issue is you can't dry aluminum chloride by heating it, iirc.

Double check this though

 

[TucoSalamanca.]

20ml Propionyl Chloride
60ml toluene
34 g zinc chloride

 

[TucoSalamanca.]

I will use zinc chloride in this synthesis How many g of zinc chloride should I use in this synthesis?

 

[G.Patton]

Same molar ratio as for AlCl3

 

[TucoSalamanca.]

how many degrees should not exceed when adding propinol chloride