Pregabalin How can I synthesize

lamer · Sep 9, 2024

Pregabalin How can I synthesize
I couldn't find any resources, can you help me?

The-Hive

Drugs market @rosechem sells it on the kg

lamer

I found such a source, but I'm not sure if it's accurate and I don't have the necessary measurements.

Pregabalin, also known as β-isobutyl-γ-Aminobutyric acid or Lyrica, is a medication used to treat epilepsy, neuropathic pain, anxiety disorders, and fibromyalgia.
The synthesis of pregabalin involves several steps starting from 4-methyl-2-pentanone. Here's a brief overview of the synthesis process:
Conversion of 4-methyl-2-pentanone to 4-methylvalerophenone: In this step, 4-methyl-2-pentanone is treated with ethylmagnesium bromide to yield 4-methylvalerophenone.
Formation of enamine: The 4-methylvalerophenone is reacted with cyclohexanone in the presence of base to form an enamine intermediate.
Alkylation: The enamine intermediate is alkylated with bromoacetic acid in the presence of base to form the key intermediate, 3-(2-bromoacetyl)-4-methylvalerophenone.
Cyclization: The key intermediate is cyclized with ammonia to form 3-(aminomethyl)-5-methyl-hexanoic acid, which is then converted to pregabalin by subsequent steps involving protection and deprotection of amino groups.
The complete synthesis reaction can be represented as follows:
Step 1: 4-methyl-2-pentanone + Ethylmagnesium bromide → 4-methylvalerophenone
Step 2: 4-methylvalerophenone + Cyclohexanone + Base → Enamine intermediate
Step 3: Enamine intermediate + Bromoacetic acid + Base → Key intermediate (3-(2-bromoacetyl)-4-methylvalerophenone)
Step 4: Key intermediate + Ammonia + Protection/deprotection steps → Pregabalin

bigrob

some them material are quite expensive u can pick up a kg here for very cheap i would look into other avenues instead of synthesising this