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Yeah apologies about this. I wrote this a while ago before I’d actually started looking into PEA chemistry. Iv definitely heard of 5-MEO-pyrolidinetryptamine and I believe a fluorinated one as well that came out the Nichols lab. I mean, it doesn’t sound pleasant really but is an interesting one...

@Swirly Hey man, when you were talking about the fact that with 2,5-DMONS you were able to get it to go fully white, and with TMO it was always slightly yellow, so you mean before you added the catalyst? Obviously when you start adding the catalyst it starts going darker and darker so I’m...

Dammit I just tried this again and completely bloody forgot to cool. It’s annoying, whenever I have done this reaction, just after adding the catalyst it starts going brown, then black and as I understand it, when phase separation happens, the black Cu is meant to stay in the aqueous layer but...

Alright, glad Im not the only one who thought it said to add the CuCl2 solution dropwise…

Whoops, I now know enough to know that ent how it’s done! Ha either way it is still using a speeter/anthony method I just got the precursor wrong!

Oh yeah, I followed his synthesis of the sodium ethyl sulfate but then I realised I can just buy a mix of nitroethane and DCM in this country as an acrylic bonder… id like to try this one day though

This is a lovely synthesis…. Iv always wanted to try this on 4-AcO-indole using dimethylamine to be honest. I would assume it would work nicely to produce 4-AcO-DMT but I’m not at that skill level yet. I’d probably kill myself at this stage so I better not try it yet! Ha

This was really useful to see the workup performed in front of my eyes…. I’m not really planning on doing this with much P2NP BUT I do have various substituted nitrostyrene’s and nitropropene’s that I DO need to reduce…. I tried it once but I don’t think I actually added enough CuCl2 as i...

I’m working on it (sort of)…. trouble is I don’t sell ha

think I may have heard about this paper, I’ll have a look…. i know the chem is way over my head for the moment, in a practical sense. I’m still trying to reduce the 3,4,5-TMONS I have made to the corresponding PEA. Iv managed it once in real bad yields via the NaBH4/CuCl2 method but not enough...

ahhh okay. Yes this makes more sense to me. I will admit I tried it a couple of times and the first time got nothing, second time I got a small amount of V dirty looking freebase. I ended up transitioning to try reducing using zinc/hcl… I def got way more crude product out of it but then I...

I’m curious how after basifying, you are expecting the amine to be in the aqueous layer? Surely you want to first acidify it to migrate it to the aqueous layer, and THEN basics, causing the amine to be deprotonated, causing it to crash out and THEN you can extract with something like DCM? I...

Or one could LITERALLY just use the ‘methanol’ solution that comes over and one was using for blood cleaning! I literally ran the Henry reaction on 3,4,5-TMOBA at room temp yesterday using the 9% mix of methanol and NM that I assume is the azeotrope. I used ethylenediamine and GAA as the...

Ahhh okay I get you. That all makes sense… Honestly, I used my first lot of the 3,4,5-NS in the first reaction and didn’t get squat out of it (5g scale). Not exactly sure where I went wrong but it certainly didn’t get too hot but I also didn’t let it react for very long at all….I just know...

Yeah I’m literally just testing on a 5g scale at the moment. Iv been learning and due to the fact there is such a difference in the amount being added, I’m assuming I didn’t reflux it long enough. I think I was expecting it to be way more exothermic than it was, due to the fact I did such a...

Could be, someone else mentioned using a superglue as a catalyst for both the 3,4,5-TMOBA condensation reaction as well as the 2,5-DMOBA one, that sounded interesting, mainly coz I’m working with 3,4,5 atm and anything I can do to reduce my use of NM would be good. Hang on let me look in my...

This is bugging me - I’m about to perform your reaction and have scaled everything down but I still find myself wondering this… Why do you say to add the b-3,4,5-TMONS in portions as a powder, as opposed to dissolving it and adding dropwise? Is it a scale thing that I’m missing because I have...

One more thing re-pumps. I’m pretty amazed mine does still work as I added the total wrong oil to it! I’d lost the manual that came with it, bought this vacuum pump oil and when it came it was orange lol so I filled her up and I noticed when I turned it on it smelled like a garage with cars...

Oh and yes I tried using one of them aspiration’s from china and it was shit! Couldn’t connect it to my tap well at all! Connected it to my water pump and (fart sound)!

Oh also regarding crystallisation of DMT from tryptamine via reductive animation at cool temps, I have found that once I have the crude DCM mix; the quicker I go ahead and remove the solvent and then re-x, the better crystallisation I get. No idea why, I also have to use a ***** ton of heptane...