Hello fellow chemistry enthusiasts,
I have personally not looked to much in the preparation of 4-Methylpropiophenone.
I have thought of a synthesis of it using succinic anhydrid on toluene using a simple Friedel–Crafts reaction with Aluminum Chloride as a catalyst, yielding 4-(4-methylphenyl)-4-oxobutanoic acid which is then decarboxylated to 4-Methylpropiophenone. The precursors seem to be widely available and relatively cheap.
If someone knows more about potential yields, or mistakes I made please let me know, because I might try it out myself.
I have personally not looked to much in the preparation of 4-Methylpropiophenone.
I have thought of a synthesis of it using succinic anhydrid on toluene using a simple Friedel–Crafts reaction with Aluminum Chloride as a catalyst, yielding 4-(4-methylphenyl)-4-oxobutanoic acid which is then decarboxylated to 4-Methylpropiophenone. The precursors seem to be widely available and relatively cheap.
If someone knows more about potential yields, or mistakes I made please let me know, because I might try it out myself.