Question Replacing Diethylmethylamine In LSD synthesis

CryoThio

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I'm wondering if another non-nucleophilic base like diisopropylethylamine can replace diethylmethylamine in the PyBOP synthesis of LSD
 

HerrHaber

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most probably yes, but yields and times will vary and I'd rather go for the one known to be successful
 

CryoThio

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Someone on reddit confirmed it was indeed a suitable replacement. Yields, idk, but it will work.
 

HerrHaber

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diisopropyl ehyl amine maybe...
 

CryoThio

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DEIsoP can be used, guy on a recently defunct chemistry subreddit proved it.
 
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