Phencyclidine (P*****) synthesis

[tripeep]

in scheme 4, how does it mean to treat with sufficient ammonium hydroxide and a saturated solution of NH4Cl until the precipitate dissolves. and how much weight is needed?

 

[G.Patton]

 

[tripeep]

???

 

[G.Patton]

Sorry, there was a bug.

 

[the money]

 

[wish690]

"Note that use of phenyl lithium instead of phenylmagnesium bromide results in failure via addition to the nitrile rather than displacement. However, in the presence of a Lewis acid, phenyllithium will displace the nitrile group and yield the desired product. Primary amino analogs of PCC, such as N-ethylamino cyclohexanecarbonitrile will produce the desired P***** analogs by reaction with 3 moles of phenyllithium.
"

What does it mean? Is Lewis acid required for PCE and other primary amino analogs with nitrile method and phenyl lithium? Or is it only for P*****? Which Lewis acid is best?

 

[G.Patton]

A guess so, AlCl3 is suitable in this case

 

[wish690]

AlCl3 must be dropped in phenyllithium before nitrile? How much?

 

[G.Patton]

The catalytic amount, I suppose.