Help : Nitrostyrene > 2C-H> 2C-B

[LSD>LDS]

Well Howdy there folks! There’s a lot of info and conversations and loosely, reliable syntheses on many forums discussing using 2 particular reagents, but I need something objective.

I’m looking for this “gold standard” synth everyone is having success with using Sodium Borohydride and Copper Chloride.

Can I pretty much just follow
BBexperts lead on his video pertaining to the amph- reductive amination? (The one detailing the use of NaBH4 +CuCl2 )but instead, use 2,5 DMNS as a substitution for pN2P>amphetamine.
Will this arrangement get a proper efficient reduction of
2,5 dimethoxyNS> 2C-H? as far as procedures and solvents?)

what solvent (s) are best here? Some say anhydrous. Some have water and alcohol. Some say no methanol. You get where I’m at here. The internet needs a solid practical workup.

There is a multitude of synths “reducing “ to arguments. “Or I tried this and got that. This might work but”. And So on.
objective? No.
Couldni be so blessed as to hear a whisper” what’s the “gold standard” kissed by Jesus, caressed by Buddha synth? “
(Please, No synths molested by Moroni here please. )
I got enough of that already.

much love folks.
your contribution would be held with gratitude.

take care,
JesusTits.

 

[HerrHaber]

beta nitrostyrenes are much more different to reduce for example aluminium amalgam just won't work (I promise... not by the same method as for p2np at least) tou may try NaBH4/Cu++ but please do it on a tiny scale not to be wasteful since there is no reason for me to believe it should work well. My best advice is for you to get RedAl (sodium bismethoxyethoxy aluminium hydride) that comes in 65-70% suspension in toluene and isn't pyrophoric, the other way is LiAlH4 the classical route. Good luck and be safe!

 

[LSD>LDS]

what about Amberlight? Ion exchange resins apparently when impregnated with sodium borohydride, they are effective in this reduction but once again, information scarcity. Do you think the convenience would raise eyebrows can be put to use but I hear very little about it.

 

[HerrHaber]

amberlyst you mean?

 

[LSD>LDS]

Amberlite® IRA-400 chloride form​

https://www.sigmaaldrich.com/MX/es/search/60177-39-1?focus=products&page=1&perpage=30&sort=relevance&term=60177-39-1&type=cas_number

I will post some trials. It’s pretty damn cool. If it works

 

[Donaldduck666]

Yeah post some trials

 

[Donaldduck666]

Iv

I've been wanting the same answers myself hopefully someone replies with a bit more knowledge about this synthesis

 

[LSD>LDS]

check lower in thread.... V V V

 

[LSD>LDS]

Hard to believe there’s so much information about it, but not a single one of them comes to a good conclusion either the asshole that touts nickel chloride, has to ruin the conversation or they just don’t come to a conclusion. When somebody posts a trial, somebody has to argue something about it, so it makes it really difficult to tell what works here.

 

[Donaldduck666]

I know it's the same with me I've searched everywhere for a synthesis using NaBH4 and cucl2 but can't really find anything concrete that someone has done

 

[UWe9o12jkied91d]

Why not just follow shulgin to the letter? LiAlH concerns?

 

[LSD>LDS]

No access to LAH

 

[HerrHaber]

RedAl or I can't reccomend any other thing that could bring success (high pressure H2 and Pd/C but this is way out of reach for small labs and much more dangerous)

 

[LSD>LDS]

I have PdCl2. But No Pd/c

 

[HerrHaber]

there bis a procedure in Vogel's book that I followed with success. Good luck!

P.S. try not to set yourself on fire...

 

[LSD>LDS]

Much Appreciated. This is a nice scalable reduction that is so convenient its almost too good to be true. Thought id share because to me, it is novel. To me at least. It is the first I have found any source discussing Al & Cu. If it helps one person, after painstaking hours of combing threads for a less toxic, less dangerous, efficient & scalable nitrostyrene reduction, then my work is done. I have no idea whom that person might be...... Hopefully not someone being too " spontaneous." hehe .

 

[LSD>LDS]

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