You’d want to use acetyl chloride instead of acetic anhydride - here’s a reference to the procedure : /10.1002/hlca.19590420638
(DOI number of the paper the procedure is mentioned in) - The paper is in German but can translate if needed
Disclaimer about this post: these synthesies are taken from patent "US2997470A" which was published in the mid 1950's
So it can be assumed that the yeilds given in the synthesies listed below can be improved by using newer methods of coupling
the amine to the D-lysergic acid Nitrogen. for...