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Amine acts as electron donating group and gives tendency to revolt hydrazine. Ester protection might work, but I assume it'll make hydrazine group less nucleophilic which'll lead to loss of yields.

Really nice instruction. Oddly, I find there's not enough interests regarding tricyclic cannabinoids. Probably because multi-step complex process. There's huge potential since they can be extremely potent as much as someone wants.

Yes, good ol' nucleophilic substitution with decent-high yield. There will be small amount of 2-substituted impurities.

Since 5ClADBA is MDMB-4en-PINACA, It's most likely be N-(O-methyl-tert-leucinyl)-1H-indazole-3-carboxamide. The moiety of MDMB-4en-PINACA without 1-alkyl chain.

Outgassing will happen unless the bath temperature isn't kept way below it's bp. Methylamine is pretty volatile and evaporates easily. I can't find solubility data and enthalpy charts, so not sure about reaction spontaneity. Maybe trial and error is the answer.

China only banned these structural classes as far as I informed. I saw some media published it as 'catchall clause', seemingly with no chemical knowledge. From briefly conducted experiments with methyl spacer cannabinoids, they have somewhat strong affinity to both receptors, being slightly less...

As Marvin mentioned, you can use other Lewis bases besides MeNH2. Base acts as a catalyst(check Henry reaction) and catalytic amount is used in reaction. So your method may work, even if the solution is not exactly 40%, but reaction rate can vary. If you prepare solution that way, lots of extra...

I'd like to distill with desiccant in boiling flask if water content could be problematic. I usually use molecular seives for it. If distillate is distilled at right bp with no azeotrope, using desiccant after distillation can be done. Of course using both is most ideal. If water content is over...

I can't tell exactly what it is, but I'm pretty sure it's one of the methyl-spacer indole/indazole cannabinoid analogues or hydrazide-linked ones. After Chinese blanket ban for common cannabinoid structures, almost all imported cannabinoids we analyzed were methyl bridged cannabinoids. Almost...

Well, some solvents form azeotropes with water and they can be pretty annoying to deal with. Acetone doesn't form azeotrope w/ water so you can distill it under drying agent and further dry it with MgSO4 etc. But Isopropanol forms 7:3 azeotrope with water which boils at 80.4'C. If it's highly...

If you use reaction mixture directly, it'll contain other unreacted reactants and NaCl which will lower the solubility of methylamine. I recommend using gas generator to dissolve MeNH2 gas to other solvent. Using methanol as reaction solvent is fine, but you can use water too. I'd say it's...

It works, and personally validated in small scale. But aquiring some precursors makes it non-ideal for most chemists. Also large scale grignard reaction is just nightmare for me personally. There are much better methods that don't require exotic chemicals and sensitive reaction conditions.

LSZ is one of the lysergamide designer drug with substituted amide group. Dimethylazetidine's stereoisomeric properties affect the potency of the LSZ as trans(S,S) isomer being most potent. Stereoselective synthesis of dimethylazetidine requires chiral reaction mediating molecules and prescious...

PM'd you one of the things I'd like to share!

Probably the most practical route for lysergamide sourcing. I've been growing some for 2 years and collecting seeds. Looking forward to collect enough to do something with it.

I hope I can join the RC section soon! Got some synthesis methods for exotic chemicals I'd like to share.

Oxidation with TEMPO and hypochlorite can be done on two phase system as you mentioned. Some phase-transfer catalysts like TBA salts can help. But since it's a secondary alcohol, I assume you can use any oxidizer which can oxidize primary alcohols to aldehydes/acids, like dichromates...

For those who's interested in tryptamine analogues might be familiar with DMT synthesis by N,N-dimethylation of tryptamine with formaldehyde and NaBH3CN. This method is the best for clandestine lab environment due to easy access to reagents. The only drawback is the formation of tricyclic...

After the great safrole drought, many other precursor and synthesis methods appeared. This is one of them starting from piperine (extracted from black pepper). Personally I regard this as the easiest source for MDMA precursor. But it has some impurities in the product and uses ozone generator as...

Olivetol is an important precursor for tetrahydrocannabinol and its analogues. But since it's one of the DEA watched chemicals, not a lot of clandestine chemists are interested in classic tricyclic cannabinoid synthesis. there are several ways to synthesize olivetol, but most of them accompanies...