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I tried the chromate oxidation of codeine many years ago and unfortunately it does not work. The best way to get 14-hydroxycodeinone from codeine is to oxidize to codeine to codeinone and then hydroxylate with MnSO4 or CuSO4 and sodium thiosulfate. Experimental details for the second step can be...

Sorry, I meant to say a kilo. Yes, it is a powder, not a liquid.

Howdy folks. I've got a liter of mapa that I'm excited to convert to p2p. I need a little more info about this reaction if someone can kindly help out. What are the byproducts of this reaction? Methanol and carbon dioxide? Why is it necessary to use 36 moles of acid for 5.2 moles of MAPA...

I figured out a better way to convert the epoxide to the ketone: dissolve isosafrole epoxide in glacial acetic acid, while stirring at room temperature add a solution of GAA that has a few drops of sulfuric acid in it. There is an immediate color change indicating the conversion to the product...