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Would it be okay for you to provide any anonymous firsthand insights on cyclobutane-based and azetidine-substitute ones?

There are at least 5 simple ways to make particular enantiomer, but no reason to do that. S-Meph is a lame antidepressant, R-Meph is the source of fun, but only together they produce infamous euphoria and addiction. Setting and mental state has close to 0 effect on mephedrone action, but...

"Strong" doesn't imply "good". Consider the question about skipping crystallization and you will derive what makes it "strong" and what it actually means at least in cardiovascular terms.

Piperidine derivatives of tryptamines serve no purpose. Loss of potency and no distinctive effects. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11152992/ You mismatch tryptamine nomenclature and phenethylamine. https://en.wikipedia.org/wiki/Tryptamine#/media/File:Tryptamine_structure.svg

DET is unstable tryptamine no matter what salt you make. DPT is the much better if you need to store it long time.

93% yield is impossible under your conditions.

Crystal system you have on the first photo diverge with one racemic mephedrone HCL should form. What are results of melting point measuring and TLC?

Because of aldol condensation.

Ethanol wont cause and problems. Its methylaniline byproduct from dirty precursor.

Yes, any hypochlorite + bromide + strong acid (Cl or SO4). Any chlorate is will work too, but with less chlorine gas.

Addition to 4-MEC formation under extended reaction time under reflux in alkaline environment:

Different solvent - different tempreture range for syntesis. 2,5h is unreasonably high for reductive animation in DCM with sixfold molar addition of amine. Your traces of haloketone has nothing to do with time. Would you be kind and name us these nice impurities, so we can produce them instead...

She add amine by drops for extended period of time. Can be longer than a half an hour.

I agree with you on using solvent for more even halogen distribution. H2O2 decomposition is unlike happen unless you reflux it up to 120-130 °C. The main issue is you having all the condition for di- and tri-halogenation. Stereo parity is also questioned, but its a pure speculation.

Right and valid correction. Made a mistake, meant N,N-Dimethyl Methcatinone. Any primary amine turns into secondary if there is enough time, energy and source. Reductive amination has the similar issue. Check MDDM contamination in MDMA clandestine synthesis. Overheating and wrong reaction times...

One correction: any strong acid will start catalytic self-condensation of acetone with results of colorful tars and various unsaturated ketones.

Reagents: L-Tryptophan 31g (152 mmol); Acetophenone 100ml; Acetone anhydrous 8ml; Distilled water 300mL; Hydrochloric acid (conc. HCl 37%) 13 mL; Benzene ~300 mL; Methylene chloride 100 mL; L-tryptophan, acetophenone and Acetone was mixed in flask. Heated and stirred it until boiling under...

Reaction temperature of 65 °C is simply wrong, since 2-bromo-4'-methylpropiophenone forms of crystals and lock 4′-methylpropiophenone inside. 2b-4m melting temperature is about 77 °C and it is very far from HBr boiling point. Consequently, 75-85 °C is a sweet range for your reaction temperature...

You can use DCE and get same timings as with DCM but without boiling.

40 degrees are not possible without extended amount of water in amination reaction. 38-39 at best. 2 hours is also a nonsense. You will end with high amount of pirazines, 4-MEC (in case of excessive amount of methylamine) and possible iso-mephedrone (havent been yet confirmed by experiments).