resolution

[johski]

hey good morning people
Does anyone here happen to know about isomerism and racemate splitting/separation?
I would like to separate existing racemic methamphetamine (d- and l-isomer) so that I only have the d-meth isomer available.
Unfortunately, I find relatively little, too little... so I'll try my luck with you guys.
supposedly it should work with d-tartaric acid, but how?
would be great if someone could help me and maybe has a guide? or a link to a guide?

thank you in advance

I wish you a nice day


greeting

johski

 

[Curiousonion]

Resolution of racemic Methamphetamine​

85 parts of racemic methamphetamine are introduced into a solution of 100 parts of d-tartaric acid in 1000 parts of methyl alcohol. After protracted standing about 100 parts of the precipitated salt are aspirated off and extracted with hot ethyl alcohol. Since the d-tartrate of dextrorotary methamphetamine is readily soluble in both methyl and ethyl alcohol whereas the d-tartrate of levorotary methamphetamine is sparingly soluble both in methyl alcohol and hot ethyl alcohol an extremely simple separation of the d-tartrates of the optical antipodes of the base is effected.

 

[johski]

thanks, and how is the yield?

 

[Curiousonion]

Usually people do it repeatedly until all the d isomer is separated. The more times you do it the more you can separate.

 

[G.Patton]

Hello, you can find manual in this article. The procedure is the same for meth. Good luck.