Mescaline Guide: Sources, Synthesis, Extraction

Mescaline Guide: Sources, Synthesis, Extraction


Mescaline (3,4,5-trimethoxyphenethylamine) is a substance of plant origin. It belongs to phenylethylamine group and entheogenic class of psychoactive substances. It has mostly psychedelic effects like LSD and, to some extent, psilocybin, however, one of mescaline distinctive effects is higher level of sociability. This substance is found in cacti genera Lophophora and Echinopsis (known before as trichocereus). The most common species of the above-mentioned cacti are Peyote, San Pedro, and Peruvian Torch. These species of plants have slow goth rate, they are most commonly found in southern parts of the USA, Mexico, Central and South America. Also, some acacia species can contain certain amounts of mescaline, for example, Acacia Berlandieri and Fernasiana, however, aside from mescaline they contain significantly higher concentrations of other psychoactive substances, Chronology of mescaline use goes back at least 5000 years, there is archaeological data evident of that. Initially, either fast-growing cacti San Pedro, which tower over mountainous desert shrubs in the Andes, or slow-growing creeping Peyote were consumed. 

Mescaline Hydrochloride

There are two common production ways of mescaline: Extraction way from plant sources and reduction of Beta-nitro-3,4,5-trimethoxystyrene synthesis (cas 6316-70-7), which can be produced from 3,4,5-trimethoxybenzaldehyde.

Mescaline Plant Sources

Plant source

Amount of Mescaline

(% of dry weight)

Echinopsis lageniformis (Bolivian torch cactus, syns. Echinopsis scopulicola, Trichocereus bridgesii)

0.25-0.56; 0.85 under its synonym Echinopsis scopulicola

Leucostele terscheckii (syns Echinopsis terscheckii, Trichocereus terscheckii)

0.005 - 2.375

Peyote cactus (Lophophora williamsii)


Trichocereus macrogonus var. macrogonus (Peruvian torch, syns Echinopsis peruviana, Trichocereus peruvianus)

0.01-0.05; 0.24-0.81

Trichocereus macrogonus var. pachanoi (San Pedro cactus, syns Echinopsis pachanoi, Echinopsis santaensis, Trichocereus pachanoi)

0.23-4.7; 0.32 under its synonym Echinopsis santaensis

Trichocereus uyupampensis (syn. Echinopsis uyupampensis)


Mescaline Extraction

The simplest and the most affordable is an extraction way from San Pedro cactus (Echinopsis pachanoi) as a mescaline source. The San Pedro cactus contains a number of alkaloids, including the well-studied chemical mescaline (from 0.053% up to 4.7% of dry cactus weight), and also 3,4-dimethoxyphenethylamine, 3-Methoxytyramine, 4-hydroxy-3-methoxyphenethylamine, 4-hydroxy-3,5-dimethoxyphenethylamine, anhalonidine, anhalinine, hordenine, and tyramine.

You can read complete Mescaline Extraction From San Pedro Cactus tutorial here.


Mescaline Synthesis From Beta-nitro-3,4,5-trimethoxystyrene

A mescaline synthesis can be considered as a typical example of Beta-nitrostyrene reduction using LAH or NaBH4. By the other name it is  reduction of 3,4,5-trimethoxy­(2-nitrovinyl)benzene with lithium aluminum hydride or sodium borohydride. There are different names of this reaction but they mean one method. 

Beta-nitro-3,4,5-trimethoxystyrene can be obtained from from 3,4,5-trimethoxybenzaldehyde. Both detailed and clear synthesis write ups can be found on BB Forum.

Beta-nitro-3,4,5-trimethoxystyrene Synthesis (cas 6316-70-7) From 3,4,5-Trimethoxybenzaldehyde

Beta-nitro-3,4,5-Trimethoxystyrene reduction With NaBH4/CuCl2 to Mescaline

[GALLERY=media, 54][/GALLERY]


In conclusion, mescaline extraction from the San Pedro cactus is identified as the simplest and most affordable method. Furthermore, the alternative synthesis route using Beta-nitro-3,4,5-trimethoxystyrene highlights the versatility of production methods. Whether derived from plants or synthesized through chemical processes, the exploration and application of mescaline are in a constant state of evolution, generating heightened scientific and cultural interest in this fascinating psychoactive compound.

  1. fidelis

    mescaline via catalytic hydrogenation

    original synth by krz ^_^ 3,4,5-trimethoxynitrostyrene: Place the following in a 2L RBF: ✮ 250g 3,4,5-Trimethoxybenzaldehyde ✮ 500ml Nitromethane ✮ 10g Ammonium Acetate (anhydrous) Procedure: ✮ Gently reflux for 5-6 hours ✮ Cool and distill off any residual nitromethane If the crystaline mass...
  2. L

    Easiest Way To Synthesize Mescaline HCL

    Hey guys, I'm a very amateur chemist who has been doing a fair amount of research (along with my friend who is an experienced chemist) into synthesis of mescaline hcl. Can anyone point me in the direction of a relatively simple (and safe) way to synthesize this compound? Thanks
  3. Novator

    Mescaline and TMA synthesis (+Their Analogues). Video Manual.

    ✅This method is suitable for the synthesis of Mescaline and its analogues (look Pihkal). ☣️Exhaust ventilation, respiratory and eye protection are needed.
  4. G.Patton

    Mescaline Extraction From San Pedro Cactus

    Introduction So, you bought your first San Pedro cutting, what now? Filter cloth method allows extracting Mescaline from Echinopsis pachanoi. Reading about the San Pedro history, current use and effects made you eager to explore. Now you're ready to dive a little deeper, into the methods of...
  5. Brain


    Mescaline (3,4,5-trimethoxyphenethylamine) is a substance of plant origin. It belongs to phenylethylamine group and entheogenic class of psychoactive substances. It has mostly psychedelic effects like LSD and, to some extent, psilocybin, however, one of mescaline distinctive effects is higher...

    TMA Synthesis by 1-(2,4,5-Trimethoxyphenyl)-2-nitropropene (3,4,5-TMPNP) LAH Reduction

    This synthesis of mescaline and TMA can be considered as a typical example of recovery using LAH. The differences in the production of mescaline and TMA are only one: for mescaline, it is necessary to take 3,4,5-trimethoxy-phenyl-nitrostyrene, and for TMA - 3,4,5-trimethoxy-phenyl-nitropropene...
  7. WillD

    Mescaline Synthesis With Nitromethane. 1000g Scale.

    Reagents: 3,4,5-Trimethoxybenzaldehyde (cas 86-81-7) 1000 g; Acetic acid 5 L; Nitromethane (cas 75-52-5) 2 L; Cyclohexylamine (cas 108-91-8) 100 ml; Distilled water ~17 L; Isopropyl alcohol (IPA) ~23 L; Sodium borohydride (NaBH4) 1200 g; Copper chloride (CuCl2) 72 g; Sodium hydroxide (NaOH) 25%...

    General schemes of amphetamine synthesis

    Most popular amphetamine-type drugs are synthesized similarly. The main precursors benzaldehyde, which is condensed with nitroethane or nitromethane to obtain the appropriate phenyl-nitropropene (PNP) or phenyl-nitrostyrene (PNS), and then the resulting PNP or FNS is reduced to amphetamine or...
  • Free product samples

    Testing products from new vendors and manufacturers.

    Get free samples for testing now!

  • Always stay in touch with BB forum. Element/Matrix.

    Connect notifications to always stay in touch with the forum!